Plan of Action Radiographs of the Left Stifle: 2 Views: With cranial Cruciate ligament rupture we expect normal bone structure, minimal soft tissue swelling. Due to acute nature of injury, we do not expect radiographic changes such as osteophytes, or thickening of the joint capsule. For neoplasia we expect to see increased soft tissue opacity around stifle joint, bony lysis, bony proliferation, soft tissue swelling, possible fracture of distal femur, and elevation of the periosteum. The pathologic changes seen with osteoarthritis can be described by an irregular distribution of cartilage loss especially in areas of increased load, subchondral cysts, subchondral bone sclerosis, osteophytes on the margins of the joint. Ultrasound: To evaluate structure and patency of ligaments and tendons. We expect all tendons and ligament to be normal except the cranial cruciate ligament. Possibly the meniscal ligaments and the caudal cruciate could be damaged. This test should prove one way or the other. Joint Fluid Evaluation: Signs of sepsis and infection as well as immune mediated disorders Arthroscopy: Visualization of CCL and meniscal ligament to evaluate damage CBC Profile: We would expect to see an inflammatory leukogram and possibly a superimposed stress leukogram. MRI: Same as arthroscopy Thoracic radiographs: In the case of neoplasia, may see metastasis- typically discrete round, soft tissue density nodules. Bone Biopsy: For neoplasia, necessary for definite diagnosis. Expect to see neoplastic cells from soft tissue and bony components. Lymph node aspirate: To check for metastasis from neoplasia. The initial tests we believe are the most important for diagnosing this case include radiographs (thoracic and left stifle), CBC and Chemistry panel, and joint fluid analysis. Based on the results of these tests, we would continue with diagnostic testing depending on the clientÕs financial resources.