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This Concept Map, created with IHMC CmapTools, has information related to: Immunology, natual killer cells recognize MHC 1, pathogens are non-self, somatically generated receptors based on rearrangement of genes in each cell, hard-wired genes fixed by selection over evolutionary time, natual killer cells belong to innate immune system, lymphocytes belong to adaptive immune system, pattern recognition receptors (PRR) hard-wired hard-wired genes, T cells are types of lymphocytes, bone marrow produces B cells, thymus produces T cells, B cells express, with extremely high variation somatically generated receptors, pathogens do not express MHC 1, T cells express, with extremely high variation somatically generated receptors, nucleated human cell are self, nucleated human cell expresses MHC 1, B cells are types of lymphocytes