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This Concept Map, created with IHMC CmapTools, has information related to: Antibiotics anti-cell wall, β-Lactams ∅ crosslink peptidoglycans ∴ autolysins, b-cidal Cephalosporins Cephamycins, Penicillins Rest: plasmid-enc. BLase ∴BLase inhib Carbenicillin, Tic., Pip., Rx G(-) (pseudomonas), broad, Cephalosporins Cephamycins wider spec, heartier, pkinetic 3rd Gen, ↑spec, ↑BLase protct Rx Enter.bact P. Aeruginosa, Penicillins Rest: plasmid-enc. BLase ∴BLase inhib Ampicillin (1st broad) Rx Escherichia, Hemophilus, Proteus, Random 4 Rx mycobacteria rst- ↓uptake, Δsite Isoniazid - b-cidal replic. bact - ∅ mycolic acid & elong fat acid, β-Lactams ∅ crosslink peptidoglycans ∴ autolysins, b-cidal Penicillins, Random 4 Rx mycobacteria rst- ↓uptake, Δsite Ethambutol -∅ cell wall arabino-galactan, Antibiotics ∅ cell wall Polypeptides, Antibiotics ∅ cell wall β-Lactams, Polypeptides Bacitracin ∅ dephos/recycle of lipid carrier Rx G+, topical (staph/strep A), Cephalosporins Cephamycins wider spec, heartier, pkinetic 2nd Gen, ↑spec Rx bact. fragilis, Glycopeptides ∅ cell wall (bridges via D-al-D-al) Vancomycin rst: E. Faeciu/Faecalis, Polypeptides Polymyxins B&E Rx G- bacilli nephrotoxic, only external, Antibiotics ∅ cell wall Random 4, Antibiotics ∅ cell wall Glycopeptides, Polypeptides Polymyxins displace Mg/Ca from outer mem ↑mem perm. Rx G-, topical (staph/strep A), Penicillins Rest: plasmid-enc. BLase ∴BLase inhib Nafcillin, Oxac., Metha. Rx Staph, Random 4 Rx mycobacteria rst- ↓uptake, Δsite Cycloserine -∅ D-ala-D-ala synth, Random 4 Rx mycobacteria rst- ↓uptake, Δsite Ethionamide -deriv of INH -∅ mycolic acid, Cephalosporins Cephamycins wider spec, heartier, pkinetic 1st Gen Rx ecoli, klebsiella, ox-suscept G+ cocci