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This Concept Map, created with IHMC CmapTools, has information related to: MELAS.cmap, Patient presents with Slurred speech, High ATP consumption tissues including Skeletal muscle, Lactate is a product of anaerobic glycolysis, Mother by Replicative segregation, Heteroplasmy percentage can determine Severity of symptoms, Brain pathologies include Hypodensity in the right temporoparietal and occipital cortices, Lactate results in Elevated serum lactate, Mitochondrial DNA (mtDNA) encodes 13 proteins involved in oxidative phosphorylation, Medical History includes Low weight, childhood, point mutation is characterized by A to G transition at np 3243, status epilepticus is a prolonged seizure, Electroencephalogram revealed Moderate slowing of conduction in right hemisphere, Family history includes Maternal relatives (mother, gmother, muncle), Patient presents with Vomitting, Family history includes Younger sister, Brain pathologies include Acute ischemic infarct, mild exercise caused Fatigue, Patient diagnosed with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes (MELAS), Younger sister is Symptomless, NADH Dehydrogenase (Complex I) when impaired/absent, inhibit Electron transport chain