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This Concept Map, created with IHMC CmapTools, has information related to: Signaling Pathways, APC mutations loss of heterozygozity, Hedgehog abberant signals BCC, PIP2 PI3K PIP3, Wnt also important for hair follicle development, 85% of sporadic BCC treated with surgery, APC mutations often occur in middle of protein (middle is worse than the end), EGFR Binds To PI3K Lipid kinase, RAF (ser-thr kinase) phosphorylates MEK, beta-catenin unphosphoryalted by APC complex Activaotr for Wnt target genes, Patched receptor Inactivating mutations Gorin Syndrome, APC mutations germline mutation= FAP, 15% of sporadic BCC treated with surgery, Smoothened receptor activates GLI, loss of heterozygozity leads to initiaition of colon cancer progression, Gorin Syndrome inheritance autosomal dominant, Wnt also important for neural devleopment, COX inhibitors (aspirin) prevent initiaition of colon cancer progression, Frizzled receptor+ LRP Co-receptor binds to APC, EGFR Binds To GRB2, APC mutations truncated protein