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This Concept Map, created with IHMC CmapTools, has information related to: hyperhomocysteinemia, DNA synthesis results in megaloblastic anemia, secretion into blood from liver causes Homocystinuria, pyrimidine sytnthesis yields dUMP, dUMP to produce dTMP, S-adenosylmathione (SAM) by methionine adenosyltransferase, glutathione is an important antioxidant, secretion into blood from liver causes oxidative stress (from the production of oxidants), cysteine by the action of Vit B6 dependent enzymes, 5-methyltetrahydrofolate (5-MTHF) which is produced by methylenetetrahydrofolate reductase (MTHFR), tetrahydrofolate (THF) is remethylated to 5,10 methylenetetrahydrofolate, pyridoxal phosphate is the metabolically active form of Vitamin B6, transsulfuration occurs in kidney, elevated plasma homocysteine (38umol/L) leads to diagnosis of moderate hyperhomocysteinemia, MTHFR gene codes for methylenetetrahydrofolate reductase (MTHFR), transsulfuration occurs in liver, betaine synthesized in liver by choline, 5-methyltetrahydrofolate (5-MTHF) metabolically acitve form of dietary Folic acid, transsulfuration occurs in GI, vascular inflammation results in 50% stenosis of carotid A, cobalamin-dependent methionine synthase requires Vitamin B12