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This Concept Map, created with IHMC CmapTools, has information related to: b4-Hyperhomocysteinemia, neurotransmitter production resulting in neurological abnormalities, C677 --> T variant in gene coding for MTHF reductase, nitric oxide-mediated dilation of blood vessels increasing risk of vascular disease and stroke, homocysteine in the urine, hyperhomocysteinemia resulting in disulfide exchange and aminoacylation reactions, folic acid is reduced to dihydrofolate, pyrimidines resulting in megaloblastic anemia, homocysteine in the blood, homocysteine in the blood, methionine synthase reductase (MTRR) transfers methyl to cobalamin (II), homocysteine in the urine, detoxification capabilities contributing to oxidative stress, MTHF reductase to 5-methyltetra- hydrofolate, GENETIC DEFECTS such as C677 --> T variant, methyl- cobalamin serves as methyl donor for methionine synthase, a healthy diet contains vitamin B12, homocysteine in the urine, methionine synthase reductase (MTRR) to S-adenosylhomocysteine, blood known as hyperhomocysteinemia, vascular inflammation which may lead to dysfunction of blood vessel endothelium