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This Concept Map, created with IHMC CmapTools, has information related to: Serena Douglas - A9, M2 Macrophage in response to TGF-B, Apoptosis absence of which leads to ulcerated tumor in rectosigmoidal flexure, Hematocrit supporting diagnosis of Anemia, M2 Macrophage which release IL-1R decoy, TGF-B become Tumor associated macrophages, constipation as a result of ulcerated tumor in rectosigmoidal flexure, Immunohistochemistry showed positive staining for CD163, unexplained weight loss as a result of ulcerated tumor in rectosigmoidal flexure, CCL17 promoting Immunosubversion, Family history of more than 2 generations with cholorectal cancer or endometral canncer, IL-1R decoy promoting Immunosubversion, CD8 Cytotoxic Tcell which mediates Antitumor immunity, ulcerated tumor in rectosigmoidal flexure in Serena Douglas, Hemoglobin supporting diagnosis of Anemia, Positive Guaiac test indicitive of blood in stool, MLH1 loss of which results in mismatch repair, M2 Macrophage which release CCL17, CBC showed decreased Hemoglobin, CCL22 promoting Immunosubversion, MSH2 loss of which results in mismatch repair