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This Concept Map, created with IHMC CmapTools, has information related to: Module 2 - Axis Specification & Early Patterning, amphibians contain dorsal blastopore lip, dorsal blastopore lip gives rise to the head, Zygotic Genes include Gap Genes, multipotent are specialized stem cells, pluripotent gives rise to first restriction to potency, fushi tarazu high conc activates Engrailed, hunchback depending on concentration, Homeotic Genes which leads to directed development of specific body structures, Hedgehog which binds Patched, ventral side (BMP4) through binding to target receptor so no interaction with BMP4, Pair Rule Genes include even-skipped, Bicoid activates Giant, even-skipped high conc activates Engrailed, extracelluar cell to cell communication through ligands and secondary messengers to establishe anterior and posterior in each parasegment (adult structure), Pair Rule Genes encode transcription factors, chordin inhibits morphogen of ventral side (BMP4), dorsal blastopore lip secretes chordin, concentration activates or inhibits Giant, dorsal blastopore lip also known as the organizer, Pair Rule Genes include hairy