Trade competition along with international politics became rough during the War of Spanish Succession/Queen Anne's War (1702-1713).  By the Close of 17th Century the English of South Carolina were in notable competition with French Louisiana for Indian trade and were in almost constant conflict with Spanish West Florida.  By 1700 d'Iberville sees the English intent for not only taking over the trade with the western Indians but as a first step in taking control of the Mississippi Valley and tries in vain to dislodge the English traders from the Chickasaw tribes.  In 1702 d'Iberville reconciled the Choctaw with the aggressive Chicasaw and promised trade would be established in their midst.  A short time later the truce was expanded to other tribes in the area.  This was not a purely defensive move.  d'Iberville wanted to expand 
Cruise 3
French commerce with the Indians and with the help of the Spanish strike back at advancing English trade maneuvers.  The English armed their Indian allies and sent them on slave hunts into the lands of the Indian allies under Spanish control-gaining profitable assets (slaves) and weakening the Spanish control in the process.1  By the onset of the War the English had already undermanned foreign control through the Indian trade system for not only the Spanish controlled lands but also for the newly started French Louisiana.2  It took less than three decades from the start of the English colony for the South Carolinians to stretch their trade to the opposite side of the Mississippi River.  In the 1704 Apalachee expedition South Carolina governors send 1000 friendly Indians and 50 whites to capture the Spanish frontier Apalachee.  This had the effect of taking away the Spanish and French retaliatory base. In 1708 Pensacola town was burned, the fort barely escaped capture and scheming for the destruction of Mobile and Louisiana was under way.3  It was the Indians not the colonies (French or Spanish) that brought the English under control.  During the Yamasee-Creek Rising (1715-1717) the raiding Indians nearly destroy the English presence.4  The French and Spanish took good advantage of this two-year war to reclaim their hold on the western Indians alliance.  The Spanish were prime for Creek alliance and the French retook their alliance with the Mississippi Valley tribes. 

1Verner W. Crane. The Southern Frontier in Queen Anne's War (1919), 381.

2 Ibid, 387-388.
3 Ibid, 389.
4 Ibid, 394.