Alpha thalassaemia major is the result of haemoglobin that has 
no alpha chains and is fatal at birth. Those affected with 
alpha thalassaemia major have mutations in both copies of their 
alpha haemoglobin chain genes resulting in all of their haemoglobin 
either lacking, or having impaired, alpha chains. The disorder is 
also called Hb Bart's hydrops fetalis.