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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 4-4, genetic changes affecting (one or both) Protein structure, Protein structure is determined by genes encoding amino acids in the reading frame, Proto-oncogenes can be activated by genetic changes, genetic changes can be as simple as single base-pair replacement, Protien expression when constant is called Constitutive, Protien expression when shut down is called Repression, genetic changes affecting (one or both) Protien expression, single base-pair replacement aka Point mutation