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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 5-7, Wnt binds to Frizzled family, serpentine contribute to few cancers, C-terminal end that migrate to the nucleus, receptors enable cells, Patched inhibits Smoothened, receptors are categorized in serpentine, Gli that migrate to the nucleus, cancers described in Chapter 6, ligand binds to serpentine, cytokine receptors ex thrombopoietin, receptors are categorized in cytokine receptors, serpentine has multiple transmembrane domains, Hedgehog binds and inactivates Patched, TGF-β receptors function as heterodimers, thrombopoietin controls development of megakaryocytes, ECM is a meshwork of proteoglycans, α subunit of G protein dissociates from β+γ pair, cells to communicate with their environment, type I which gets activated and phosphorylates cytosolic proteins, proteolysis which frees the C-terminal end