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This Concept Map, created with IHMC CmapTools, has information related to: Ch 3&4, specific phenotypes eg Reduced requirement for growth factors, Proto-oncogene is activated to become Oncogene, Temperature sensitive mutants at the Permissive temperature, specific phenotypes eg Tumorigenicity, Rous Sarcoma Virus exhibited RNA to DNA conversion, transformation above the Nonpermissive temperature, Genome as large as 125 kB, Oncoproteins cause cell changes associated with Cancer, Nonpermissive temperature causes protein degradation, Rous Sarcoma Virus in chicken tumors, specific phenotypes eg Increased glucose transport, specific phenotypes eg Immortalization, v-src is found in Tumor Virus, Bishop and Varmus created DNA probe, Tumor cells exhibit specific phenotypes, Proto-oncogene eg c-src, Tumor Virus have been shown to cause Cancer, reverse transcription revolutionized field of molecular biology, src gene discovering it was present in Tumor cells, Howard Temin discovered RNA to DNA conversion