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This Concept Map has information related to: Class Notes 9.10&9.13 Chapter 5 growth factors&receptors, protein signaling uses integrins, gene fusion is irreversible, HER2 receptor therapy does not inhibit repector, the lignad binds activating the noncovalently linked tyrosine kinases, Notch Receptors Cleaved when ligand binds, noncovalently linked tyrosine kinases that transphosphorylate, transphosphorylate resulting in phosphorylation of receptor tails, epidermal growth factors cause carcinomas, serine/theronine kinase domain forms a heterodimer, TGF-B receptors is an example of receptor amplification