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This Concept Map, created with IHMC CmapTools, has information related to: 5.5-5.8, effector loop see fig 6.13, GTP then binds Raf, cytokines control thrombopoiesis, PIP3 by cleaving a phosphoinositol, MEK phosphorylates and activates Erk2, Rho-GEFs activate Rho proeins, cytoskeleton proteins i.e. lamellipodia, MEK phosphorylates and activates Erk1, Stat3 is constitutively actuvated, Bad inhibits apoptosis, dimerization of Jak tyrosine kinases phosphorylates Stat3, specificity through functional activation, Akt/PKB Activates Bad, Pl3k activates PIP3, STAT 1 to activate transcription factors, a phosphoinositol is an example of second messengers, STAT 2 to activate transcription factors, Jak-STAT pathway involves dimerization of Jak tyrosine kinases, GSK-3B stimulates cell proliferation, mTOR stimulates cell growth