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This Concept Map, created with IHMC CmapTools, has information related to: Ch 5, receptors can lead to the development of cancer cells, integrins function in signaling pathways, serpentine receptors work to activate G proteins, movement/migration is a property of all undifferentiated cells, ligand binding activates receptors, Herceptin is an antibody that binds to HER2-R, autophosphorylate signal proteins is deleterious because this bypasses signaling regulatory mechanisms, receptors can theoretically be corrected by gene therapy, 30% of Breast Cancers can be treated with Herceptin, point mutation in transmembrane region causes 30% of Breast Cancers, Smoothened allowing cleavage of GLi, integrins function in the metastatic cascade, signaling pathways allow cell to cell communication, replication deficient viruses allows for targeted cell localization, receptors eg Patched-smoothened signal system, Patched inhibits Smoothened, antibodies eg Herceptin, receptors eg serpentine receptors, Serine or Threonine Kinases are found ubiquitously in mature cells, constitutive dimerization of receptor aka constitutive activation of signaling pathway