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This Concept Map, created with IHMC CmapTools, has information related to: 6-10 Concepts, β-catenin binds to E-cadherin, axin which attaches to GSK-3β, β-catenin moves to the nucleus, wnt-β-catenin pathway contributes to cell proliferation, β-catenin forms a complex with axin, wnt signaling blocks GSK-3β, undifferentiated state as we will learn in Chapter 7, apc which attaches to GSK-3β, nucleus and activates expression of myc, intestinal stem cells make them remain in an undifferentiated state, colon carcinomas have defective apc, β-catenin forms a complex with apc, colon carcinomas will be discussed in the next chapter, myc as we will study in Chapter 8, colon carcinomas have defective degradation of β-catenin, E-cadherin forms adherens junctions, β-catenin at high levels in intestinal stem cells