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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 5 discussion, Transforming Growth Factor-β (TGF-β) in Normal cells, Cell signals can come from Paracrine signalling system, Cell motility needs to be Justified, Increased sensitivity leading to Constitutive activation, Constitutively dimerized in Breast Cancer, Clustering of membrane bound proteins leads to Endocytosis, Tyrosine Kinases are active only after undergoing Dimerization, Integrin receptors are involved in Cell motility, Herceptin is an Antibody, Integrin receptors are important to Metastatic infection, Tyrosine Kinases include Src, Metastatic infection is a form of Dedifferentiation, Tyrosine Kinases are Evolutionarily conserved, Cancer treatment can use Protein targets, Dimerization is not specific to Tyrosine Kinases, Transforming Growth Factor-β (TGF-β) has different effects in Cancer cells, Cancer cells promotes Transformation, Tyrosine Kinases are A separate class of signaling, Integrin receptors inhibit Anoikis, Antibody that binds two HER2 receptor