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This Concept Map, created with IHMC CmapTools, has information related to: group discussion ch 6, Grb contains an SH2 domains, one version mutated alters the intensity of one functionality, SH2 domains activate ras, ECM if released from cell, it self destructs, PTEN downregulates TK activity, Shc links a TK to a Grb, multiple mutations increase the probability of cancer, SOS eg proline rich region, GAP eg phosphorylase, Shc contains a phospotyrosine, redundancy ex Cyclins, evolution balances energetically small number of genes, PTEN is a phosphatase, ras changes shape after receieving cell signal, PI3Kinase regulates change between PIP2-> PiP3, beta-catenin is cleaved from cadherins, non-growth pathways lead to cell death, Cyclins is actibvated by specific set of signals, Shc contains a SH3 domains, SH2 domains binds 3 adjacent AA