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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 7 merged, tumor suppressors eg gatekeepers, Familial adenomatous polyposis (FAP) is caused by mutation in APC, Familial adenomatous polyposis (FAP) leads to formation of Polyps, Genetics of Tumor Supressor Genes, LOH events 7.4 allowed for the localization of Rb 7.5, Polykaryon e.g. heterokaryon, Hyperactivated genes aka Ras Proto-oncogene, Tumor Supressor Genes 7.9 eg VHL 7.12 (Von Hippel-Lindau disease), Ras Signaling is inactivated by Ras GAP, DNA Methylation involves Caretaker Genes, genome maintenance eg caretakers, Recessive Phenotype is supressed in the presence of Dominant Phenotype, Point Mutation can more easily cause Inactivated genes, Cancer cells were though to undergo Gene Shedding, NF1 Gene codes NF1 Protein, Sporadic form required two Allelic Mutation, Neurofibromatosis Type 1 affects 1 in 3500 individuals, LOH events 7.4 lead to inactivation of Tumor Supressor Genes 7.9, HIF-1 during normoxia, Inactivated thorugh LOH