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This Concept Map, created with IHMC CmapTools, has information related to: chapter 8-4, p27Kip1 stimulate the formation of cyclin D-CDK4/6, Akt/PKB phosphorylates and thereby deactivates p21Cip1, p18INK4C affect only CDK6, p21Cip1 deactivates E-CDK2, CDK inhibitors ex p21Cip1, PI3K upregulates Akt/PKB, TGF-beta upregulates the transcription of p21Cip1, cyclin-CDK complexes are regulated by CDK inhibitors, p21Cip1 deactivates A-CDC2, p19INK4D affect only CDK4, p21Cip1 deactivates A-CDK2, p21Cip1 inhibits PCNA, CDK inhibitors ex p19INK4D, CDK inhibitors ex p16INK4A, p15INK4B affect only CDK4, p16INK4A affect only CDK4, CDK inhibitors ex p57Kip2, p21Cip1 stimulate the formation of cyclin D-CDK4/6, CDK inhibitors ex p18INK4C, PI3K was discussed in Chapter 6