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This Concept Map, created with IHMC CmapTools, has information related to: chapter 8-7, HDAC changes the conformation of chromatin, cyclin E phosphorylates and deactivates p27Kip1, E2F1 if injected can initiate mitosis, cyclin A and CDK activates expression of E2F7, promoters of other genes ex many proteins involved in late G1 phase, hyperphosphorylated and release E2Fs, E2Fs ex E2F5, E2F7 blocks E2F dependent expression, HDAC eg deacetylates histines, E2F1 is downregulated in G0 state, many proteins involved in late G1 phase ex cyclin E, E2Fs ex E2F3, E2F1 is upregulated in normal cells, E2F2 is downregulated in G0 state, hypophosphorylated and then bind to E2Fs, E2F3 is downregulated in G0 state, E2Fs ex E2F7, E2F4 associates with p130, E2F3 is upregulated in normal cells, E2F5 associates with p130