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This Concept Map, created with IHMC CmapTools, has information related to: Modified Chapter 7, p53 Gene aka TP53, 1 recessive mutation to become phenotypically expressed, Cancer has a Recessive Phenotype, Cancer requires an explanation of Genetics, APC triggers degradation of Beta-catenin, Cell Fusion can create Polykaryon, Caretaker Genes eg BRCA1 Gene, DNA Methylation is Epigenetic, esterase D gene was mapped to 13q14, dividing if there are mutations, Tumor Supressor Genes eg p16INK4A, Familial adenomatous polyposis (FAP) results from accumulation of Beta-catenin, Tumor Supressor Genes eg NF1 Gene, heterokaryon carry both a Recessive Phenotype, NF1 Gene inactivation causes Neurofibromatosis Type 1, Homozygous is created through Endogamy, angiogenesis due to induction of genes for PDGF, LOH eliminates alleles ability to be Heterozygous, LOH event would knock out Rb gene, HIF-1 during normoxia