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This Concept Map, created with IHMC CmapTools, has information related to: Ch 7 class discussion 9.24 and 9.27.07, Conductin bind Beta-catenin, APC associates with GSK-3Beta, pVHL bind HIF1-alpha and ubiquitylate, Retinoblastomas are classified under two forms, methylation pattern is maintained after replication by maintenance methylase, inherited mutation which alone does not mean tumor formation, recessive tendency for tumor formation, Mutated NF1 with an event such as LOH, hypermethylation is exploited by G0 cells, somatic mutation(s) such as translocation, Ras-GAP to turn off Ras, two forms called sporadic, proline hydroxylase allowing it to associate with pVHL, Cell fusion is achieved via introduction of a fusogenic agent, LOH is rather important for TS genes, CpGs are eligible for methylation, familial version has an inherited mutation, LOH leads to malignant tumors, APC associates with Axin, familial requires one somatic mutation(s)