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This Concept Map, created with IHMC CmapTools, has information related to: Section 8.6, D-CDK4/6 hypophosphorylates pRB, pRB guards the R-point, E-CDK2 forms Hyperphosphorylated pRB, E-CDK2 hyperphosphorylates pRB, Hyperphosphorylated pRB can no longer inhibit starting the Cell cycle clock, D-CDK4/6 forms Hypophosphorylated pRB, Hypophosphorylated pRB can pass through the R-point