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This Concept Map, created with IHMC CmapTools, has information related to: group discussion ch 7, hypermethylation eg represses gene, binding of histines prevents the work of RNAPolymerase, binding of histines prevents the work of DNA Polymerase, hypomethylation eg un-represses gene, APC mutation in the germ line can cause familial polyps, LOH can be caused by deletions, TSGs ex NF1, NF1 activates phosphatase for Ras, DNA supercoiling prevents the work of RNAPolymerase, beta-catenin eg signal that blocks cell apoptosis, NF1 can be mutated via deletion, APC interacts with another protein to break down beta-catenin, repair/prevention mechanisms ex controls cell cycle, DNA supercoiling prevents the work of DNA Polymerase, TSGs ex VHL, LOH can be caused by errors in replication, sporadic usually occurs by mutation in a somatic cell, binding of histines controls expression of genes, VHL in normoxia is ubiquitylated and destroyed, methylation is sometimes passed with DNA