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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 9 Merged Map, p53 triggered apoptosis is used only in Nonroutine, emergency situations, Bax gene inactivation as described as Chapter 12, anti-apoptotic stategies e.g. PI3K --> Akt/PKB pathway, p53 is an example of A dominant mutant, cell death may be carried out by necrosis, Cancer cells have loss of Apoptosis, Myc as described in Section 9.8, Inherited p53 inactivation is mimicked in individuals born lacking Chk2 kinase, immune system using natural killer (NK) cells, executioner caspases cleave death substrates, Tumors including Brain tumors, p53 inducers include Agents that disrupt microtubule components of the cytoskeleton, inhibitors of apoptosis (IAPs) which are anti-apoptotic, p53 inactivation allows for the continued existence of an Oncogene bearing cell, p53 inducers include myc oncogene, inhibitors of apoptosis (IAPs) which are anti-apoptotic, ARF binds and inactivated Mdm2, phosphorlated p53 is not bound by Mdm2, p53 originally believed to be an Oncogene, Tumors including Breast cancer