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This Concept Map, created with IHMC CmapTools, has information related to: Ch 8, smad3 binds smad4, proliferate aka passage through process initiating with G1 phase, degrade proteins via ubiquitination, hyperphosphorylated pRb is functionally inactive, hypophosphorylated pRb stimulate production of more cyclin E, Cyclin D acts during G1 phase, G1 phase contains Restriction (R) point, Cell Cycle Clock regulates cell cycle, Mitosis leads to G0, inhibitors which activate Cyclin D, checkpoints check for errors; if present, inhibits continuation through cell cycle, TGF-B phosphorylates smad3, E2Fs stimulate cell to proliferate, TGF-B turns off expression of myc, pRB is a pocket protein, inhibitors eg p27Kip1, E2Fs eg transcription factors, cyclins eg cyclin E, cyclin E when bound to CDK phosphorylates p27Kip1, Cyclin D when bound to CDK4/6 phosphorylates pRB