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This Concept Map, created with IHMC CmapTools, has information related to: Class discussion Chapter 8, Cyclin D is only active in nucleus, pRB is unphosphorylated, hyperphosphorylated as cell approaches Restriction point, G0 has two choices, including Differentiation, Cyclin-dependent kinases are not Degraded, Cell Cycle consists of G1, G2 proceeds to M, pRB is a Pocket protein, Differentiation aka become Post-mitotic, Signal pathways ie Ras, Cyclins are Degraded, unphosphorylated during G0, myc is oncogenic with Mutations, Cyclin-CDK complexes allow cell to pass through Checkpoints, Differentiation can reverse to Dedifferentiation, Restriction point is located at end of G1, Dedifferentiation in Cancer cells, Cyclin E inhibitors stimulate Cyclin D, Cell processes unlike Tyrosine kinases, Cyclin D is found in cytoplasm