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This Concept Map, created with IHMC CmapTools, has information related to: 10.6, 10.7, & 10.8, 6 base DNA molecule attaches it to the end of telomers, neomycin resistance gene as a marker(FIG 10.29), hRT is present and functional in pre-crisis cells, hTERT synthesizes 6 base DNA molecule, physiologic stress can cause senescence, detectable only in low levels in normal cells, replication generations causing erosion, crisis via expression of telomerase, crisis ensues after telomeres, 10-15% of cancer cells utilize ALT mechanism, telomerase is detectable, sequence exchange between telomeres aka copy choice mechanism (fig 10.30), holoenzyme consisting of several subunits including hRT, telomerase structurally is a holoenzyme, senescence can be avoided by expressing large T oncoprotein of SV40, 85-90% of cancer cells, antisense RNA complimentary to hTR RNA subunit, Transcription Factor contributing to transcription of hTERT, detectable in 85-90%, senescence can occur even in the presence of sufficiently long telomers