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This Concept Map, created with IHMC CmapTools, has information related to: Ch 9, p53 is a transcription factor, p53 functions by causing stop progression of cell cycle, p53 designs its own destruction of protein, p53 is activated by ds DNA breaks, BCL-2 functions to prevent apoptosis, SV40 contained in its serum protein, protein revealed with an autoradiogram, BCL-2 controls cyt-c exit from mitochondria, stop progression of cell cycle when inhibited, become permissive to cancer, dominant negative mutant in other words mutation allows subunits to still form tetramer, p53 functions by causing apoptosis, protein kinase inhibitors activate ATR, intrinsic eg, via p53, p53 is activated by DNA damage, dominant negative mutant in other words mutation is in DNA binding domain, ds DNA breaks are detected, activating ATM kinase, DNA damage activates protein kinase inhibitors, protein that bound to p53, transcription factor can be controlled by covalent modifications to the molecule, cyt-c exit from mitochondria leads to cell death