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This Concept Map, created with IHMC CmapTools, has information related to: class discussion 10.9 and 10.12.07, Dominant-negative is mutated form of a protein, apoptosis is regulated through initiator caspases, activating apopotosis by activating transcripiton of Bak, overactive PI3K promotes cell survival, oncogene signaling tirgger activation of p53, block of angiogenesis by aiding transcription of Tst-1, initiator caspases activate the executioner caspases, pro-apoptotic gene promoters is an epigenetic modification, Death by neglect is a cell's lack of survival signals, survival signals which leads to apoptosis, apoptosis is used during morphogenesis, epigenetic modification exploited to prevent apoptosis, apoptosis is regulated through executioner caspases, phosphorylation by Chk2, transmembrane receptor commly called a death receptor, lack of nucleotides tirgger activation of p53, Mdm2 binds and ubiquitylates p53, p53 can become Dominant-negative, p53 exists within a positive-feedback loop, executioner caspases destroy cell components