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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 9, p21 to halt the cell cycle, apoptosis is overcome in cancer cells, p53 produces Tsp-1, Bcl-2 triggers release of cytochrome c, p53 turns on when it becomes phosphorylated, mutations when it is inactivated, p53 triggers 14-3-3-sigma, apoptosis which prevents proliferation, cancer cells inactivate apoptosis, apoptosis occurs via caspases, p53 was found in cells infected with SV40 virus, p53 is regulated by ARF, telomeres do not shorten in cancer cells, apoptosis via death receptor destruction, IGFs starvation can lead to apoptosis, E2F transcription factor that acts as a convergence point in the cell cycle, mitochondria to the cytosol, ARF which is regulated by E2F transcription factor, p53 is activated by DNA damage, p53 normally undergoes degradation