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This Concept Map has information related to: Chapter Map, estrogen upreglates growth of mammary epithelial cells, nonmutagenic agents contribute to tumorigenesis, evidence reveal that normal cells, transformation requires 5 intracellular pathways, NF-kapaB pathway activates COX-2, validating Darwinian model of tumor development could be possible through identifying necessary epigenetic events, toxic agents ex distilled alcoholic drinks, initiators alter DNA, PKC-alpha indirectly leads to inflammation, intestinal epithelial tumors can be easily examined for through colonoscopy