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This Concept Map, created with IHMC CmapTools, has information related to: Ch 11 sections Vince, autocrine signaling manner and induce pre-neoplastic changes in cells, accurate comparison between populations of different geographical locations, NF-kapaB pathway activates COX-2, prostaglandin E2 evokes phenotypes of metastatic cells, longer life span for Older people, deletion of chromosomal segments, tumor cell populations become increasingly unstable, promoters induce division, Older people are more prone to Tumor formation, PKC-alpha is a promoter of skin tumorigenesis, chromosomal segments in genomes, TPA targets PKC-alpha, inflammation aids tumor progression, PGE2 can act in a autocrine, tumor cell populations of High-grade tumors cells, Tumor formation is a multi-step process, linear path of clonal succession, accurate comparison between populations of different times, PKC-alpha indirectly leads to inflammation, inactive APC gene is typically responsible for sporadic tumors