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This Concept Map, created with IHMC CmapTools, has information related to: chapter 11-8, validating Darwinian model of tumor development could be possible through identifying necessary genetic events, validating Darwinian model of tumor development requires knowledge of kinetics of each step, knowledge of kinetics of each step changes depending on cell maintenance mutations, epigenetic events could be explored by analysis of methylation states of promoters, knowledge of kinetics of each step ex point mutations frequency of 10^-6, screening for genetic transcripts could be misleading due to gene silencing because of differentiation, genetic events could be explored by screening for genetic transcripts, epigenetic events could be explored by screening for genetic transcripts, validating Darwinian model of tumor development could be possible through identifying necessary epigenetic events