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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 10 discussion, senescence does not involve the cell's replication, cell physiological stresses limit cell's replication, uneven breakage at next division occurs at a random point, end replication problem occurs because RNA primer do not always go to the end and DNA is not replicated, unstable chromosomes create more anaphase bridges, mutated upregulated cancer cells, telomerase needed to keep telomere length, cell physiological stresses i.e. oxidative stress, more divisions with fewer cels, telomerase when absent decreased tumor suseptibility, HTERT when mutated is dominant negative, mice telomers when shortened result in premature aging, telomeres can be extend through the ALT mechanism, inactive telomerase in cells with inactive p53, myc when mutant allows for imortality, Large T Antigene activates p53, cell lineage cell keeps track of number of divisions, cell lineage represented using pedigrees, breakage-fusion-bridge cycle creates anaphase bridges, holoenzyme contains hTR