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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 10, telomeres that are too short go into crisis, G-Quadruplex ligand RHPS4 was studied using fluorescent-activating cell sorting (FACS), cell-physiologic stresses e.g. DNA damage, cell divisions of one cell type form its cell lineage, hTERT is not present in mortal cells, pre-malignant tumors are called adenomas, telomerase is expressed at high levels in cancer cells, telomeric repeat amplification protocol (TRAP) measures activity of telomerase, adenomas and may be formed by initial bursts of breakage-fusion-bridge (BFB) cycles, hTERT may be targeted in anti-cancer drugs, cell divisions are measured by population doublings, human cells have short telomeres, anti-cancer drugs but its effect would require numerous cell divisions, cell-physiologic stresses limit the number of cell divisions, breakage-fusion-bridge (BFB) cycles lead to crisis, CDK inhibitors e.g. p21, CDK inhibitors halt the cell cycle, CDK inhibitors accumulate during population doublings, telomeres act as a generational clock, hTERT is required for replication of telomerase