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This Concept Map, created with IHMC CmapTools, has information related to: Discussion map, Tumorigenesis requires mutations that are Epigenetics, Clonal Selection i.e. Monoclonal, Toxic Agents can support Tumorigenesis, Genetic are affected by Initiators, Promoters are required to cause Tumors, Tumors consist of Tumor Stem Cells, Tumor Stem Cells can Divide, Tumorigenesis can lead to Cancer, Clonal Selection was Darwins answer to Cancer, Multi-step Process was validated by Ras-Oncogene, Ras-Oncogene alone cannot ause Tumors, Tumorigenesis goes through a Multi-step Process, Tumorigenesis leads to formation of Tumors, TNF-a goes through a Positive feedback loop, Tumorigenesis requires mutations that are Genetic, NSAID Inhibit COX-2, Inflammation can support Tumorigenesis, Clonal Selection did not account for Epigenetics, Inflammation can get disregulated through TNF-a, NSAID help prevent Inflammation