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This Concept Map, created with IHMC CmapTools, has information related to: Section 12-1, tissues are organized to minimize the progressive accumulation, tissues have a small stem cell compartment, normal stem cells undergo symmetric division, cancer stem cells undergo asymmetric division, normal stem cells give rise to ex enterocytes, progressive accumulation of mutations, mutations in the stem cell genome, stem cell compartment is normally not comprised of cancer stem cells, stem cell compartment is normally comprised of normal stem cells, mutator phenotype does not minimize the progressive accumulation, normal stem cells undergo asymmetric division, tissues ex gastrointestinal crypts, cancer stem cells undergo symmetric division