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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 12, Mutated by Mutagenic agents, endogenous includes Methylation, Stem cells can be Cancer stem cells, Stem cell supply sometimes maintained by Symmetrical division, Mutated by Replication error, Asymmetric DNA strand allocation studied with Tritium atom decay, Asymmetric DNA strand allocation is where nonconserved strand, Reactive oxygen species come from Peroxisomes, Pol-sigma abscence leads to Increased cancer rate, Stem cells undergo Asymmetrical division, Reactive oxygen species come from Spontaneous oxidation of lipids, Removal of mutagenes uses Mdr1 protein, Mutated by Spontaneous chemical change, Transversion is the conversion of G to T, Studies of skin cancer in mice showed Actively cycling cells were not effected, Deamination involves Loss of amine group, Hematopoietic cells can all have the Philadelphia chromosome, Long-lived cells being key to cancer e.g. Hematopoietic system, The cell that will become amplified to form the tissue result in Many mitotic divisions, Stem cells are a target for mutagenesis (Section 12.2) resulting in Stem cells avoid mutations (Section 12.3)