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This Concept Map, created with IHMC CmapTools, has information related to: Ch 11, Tumors consist of Differentiated Cells, Genetic eg Initiators, Tumor Stem Cells divide via assymetric cell division, Clonal Selection in other words Monoclonal origin of turmors, Inflammation contribute to Tumorigenesis, Multi-step Process was validated by showing Ras (and other oncogenes), Inflammation contribute to mitogenic signals, Tumorigenesis requires mutations that are Genetic, Inflammation can get disregulated through TNF-a, Toxic Agents contribute to Tumorigenesis, Initiators are required to cause Tumors, Toxic Agents contribute to mitogenic signals, Complete Carcinogens are both Initiators, Differentiated Cells are unable to create a tumor mass, NSAID are inhibitors of COX-2, Epigenetics eg Promoters, Tumors consist of Tumor Stem Cells, Ras (and other oncogenes) are not sufficient to form Tumors, Complete Carcinogens are both Promoters, Tumorigenesis is a Multi-step Process