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This Concept Map, created with IHMC CmapTools, has information related to: Section 12-12, metaphase plate includes kinetochores, interphase is characterised by a single centrosomes, centrosomes organize mitotic spindle, centrosomes are supernumerary, chromosome number may be causal, cancer cells are often formed by inherited defects, breast cancer studies show reduced DNA repair, chromosome number may be consequence, inherited defects in caretaker genes, DNA repair in lymphocytes, caretaker genes as indicated by breast cancer studies, cancer cells is often changed through alterations, chromosomal instability affects chromosome number, chromosomal instability more common than gene mutation, chromosome number can occur by nondisjunction, karyotype of cancer cells, alterations in chromosome number, supernumerary in cancer cells, centrosomes organize metaphase plate