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This Concept Map, created with IHMC CmapTools, has information related to: chapter 9 discussion map, p53 can cause apoptosis, DNA BD is most often mutated, cyclins bind and activate CDKs, E2Fs are transcription factors for cyclins, 14-3-3-sigma binds cyclin B in cytoplasm, growth factors upregulate Mdm2, p53 stabilizes telomeres, p53 was discovered through SV40 protein binding, apoptosis ex mammary cells die after baby is born, open channels into mitochondria causes the release of cytochrome c, Bax eg open channels into mitochondria, SV40 protein binding shows that stressed/mutated cells express p53, bcl2 prevents apoptosis, p53 upregulates transcription of Bak, p14ARF activates p53, p53 is normally transcribed and ubiquitylated for destruction, p21Cip1 which controls activation of E2Fs, p53 has several binding domains, caspase 9 is a major factor in apoptosis, bcl2 prevents dispersal of cytochrome c