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This Concept Map, created with IHMC CmapTools, has information related to: discussion map chapter 10, TRAP eg telomeric repeat amplification procedure, p21 and p16 prevent cell division, RNA can be deactivated by complimentary RNA, ALT mechanism occurs in 10-15% of cancers, telomeres are a measure of the number of times a cell divides, telomerase holoenzyme acts as a reverse transcriptase, complimentary RNA eg double stranded RNA gets degraded, Breakage-Fusion-Bridge sequence occurs if the cell is not in crisis and has no telomeres, telomeres are reduced in size for each cell division, telomeres length signals the cell to go into a senescent state, hTERT can be deactivated by dominant negative mutated hTERT, cell division occurs as non-exponential division, telomeres length signals the cell to go into a Crisis state, hTR deactivation causes 8 year olds look 95, telomerase holoenzyme negative cells cause reduced cancer rate in cells, telomeres can be stabilized by specific compounds, telomerase holoenzyme contains hTERT, ALT mechanism lengthens telomeres, cell immortality can occur in cancerous cells, TRAP can measure the length of telomeres