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This Concept Map, created with IHMC CmapTools, has information related to: discussion map chapter 12, changes in DNA can sometimes be corrected by repair mechanisms, changes in DNA ex microsattelite errors, changes in DNA ex deamination, changes in DNA ex depyrimidation, changes in DNA ex thymine dimers, transition mutation eg C to T transition, changes in DNA ex abasic DNA breakage, repair mechanisms ex homology-directed repair, mutated repair mechanisms ex hereditary non-polypsis colon cancer HPNCC, hereditary non-polypsis colon cancer HPNCC involves progression from adenoma to carcinoma more quickly, BRCA1 is often mutated in breast and ovarian cancer, repair mechanisms ex siRNA, repair mechanisms ex BRCA2, stem cells can be protected by physical barrier, error prone repair eg introduces mistakes, repair mechanisms ex BRCA1, changes in DNA ex adduct formation, thymine dimers are attempted to be fixed by error prone repair, changes in DNA can be somewhat prevented by XP genes, repair mechanisms ex base excision repair