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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 13 discussion, epithelial mesenchymal transition causes cells to stretch, chemotactic factors involve cytokines, cell culture lines not truly representative of cancer cells, stromal cells that are specific to the vascular system pericytes, Ras inhibits thrombospondin-1 (tsp-1), inegrins used by cell to bind to ECM, angiogenic switch release VEGF, p53 and pRb when bound inhibit apoptosis, angiogenesis results in cell proliferation, epithelial mesenchymal transition uses proteases, platelet formation converts fibringen, growth factors blocked cause cell proliferation, hemidesmosomes used by cell to bind to ECM, 2 theories are neoplastic cells, signaling can be from benign tumors, pericytes provide support for blood vessels, normal vasculature is in close contact with pericytes, signaling the theory being tumor formation, fibringen to fibrin, capillaries can form cancer vasculature