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This Concept Map, created with IHMC CmapTools, has information related to: chapter 14-4, laminin 2-gamma is an indicator of EMT, NF-kappaB when missing, prevents EMT, PI3K protects cell from cytostatic, apoptotic affects of TGF-beta, EGF epidermal GF is used for signalling by the stroma, TGF-beta activates NF-kappaB, laminin 2-gamma is cleaved to EGF-R ligand, Raf can directly cause EMT, EGF epidermal GF secretion can cause invasiveness, EGF epidermal GF concentration is increased in metastatis, IGF-1 insulin like GF is used for signalling by the stroma, EGF epidermal GF secretion can cause aggressiveness, laminin 2-gamma is cleaved by MMP, TGF-beta is used for signalling by the stroma, TGF-beta can directly cause EMT, EGF epidermal GF signals release of CSF-1 colony stimulating factor, TGF-beta activity is shown by increased nuclear Smad2 transcription factor, loss of pRb protects cell from cytostatic, apoptotic affects of TGF-beta, CSF-1 colony stimulating factor attracts TAMs tumor associated macrophages, TGF-beta feedback loop could be important to expression of alpha-v-beta6 integrin, alpha-v-beta6 integrin is an indicator of EMT