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This Concept Map, created with IHMC CmapTools, has information related to: Chapter 14 discussion, Metastasis seen through fluroescence tagging, Plasmin cleaves pro-MMPs, Metastasis occurs when tumor with blood vessels, epithelial mesenchymal transiton used in embryogenesis, macrometastasis is tumor with blood vessels, travel to new site bypasses second basement membrane, filopodia senses area, growth factors e.g. hepatocyte growth factor/scatter factor, tumor with blood vessels usually in endothelial lumen, secondary site must have similar signals, wound healing are already existing mechansims, Rho proteins proper use Rho activation, gastrulation is when cells start moving inward, epithelial mesenchymal transiton tracked using Twist (TF), tumor associated macrophages secrete growth factors, Rac proteins relates to lamelelipodia, entry to circulatory system can be breached by disruption of tissue, Twist (TF) expresses vimentin, lamelelipodia moves cell, epithelial mesenchymal transiton begins with cleavage of E-cAdherins